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| Laboratory Based
Projects
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| Drs. Jamali, Zamir and Ghadirian | Preclinical Pharmacology of Novel Drugs Derived from Natural Products in Breast Cancer |
This project by Drs. Jamali at the Lady Davis Institute, Dr. Zamir at Institut Armand Frappier, and Dr. Gadhirian at Hopital Hotel Dieu uses state of the art approaches to explore exotic vegetation for novel anti-cancer activity in breast cancer. The scientists have already identified an extract of a plant which has potent anti-tumor and anti-metastatic properties, and have recently submitted a patent, even as the work progresses further to identify the precise molecules with activity. |
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| Dr. Momparler et al. | Evaluation of 5-AZA-2'-Deoxycytidine for Breast Cancer Therapy |
Drs. Momparler and Sinnett at Université de Montreal are teaming up with Drs. Miller and Sandor at the Lady Davis at the Clinical Research Unit at the Jewish General Hospital to undertake in breast cancer patients an exploratory study of a drug that may reactivate genes that are silenced due to methylation in breast cancer cells, and when turned back on may be therapeutic targets or may stop tumor growth. |
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| Drs. Miller and Mader | Novel Hormonal Approaches to Breast Cancer Treatment |
| Drs. Wilson Miller at Lady Davis and Sylvie Mader in the Biochemistry Department at Universite de Montreal have teamed up to try to understand the interaction between breast cancer receptors for estrogen, and their responsiveness to therapy with the vitamin A derivatives called retinoids. Using novel technology, they are establishing new cell models that will help to screen libraries of retinoids more quickly, looking for those effective in breast cancer. | |
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| Drs. Hung The Huynh and Alpert | Investigation of molecular mechanism(s) underlying the effects of human chorionic gonadotropin and vitamin D on mammary gland growth and carcinogenesis |
| This proposal aims at exploring new and non-toxic treatments to prevent breast cancer. The investigators are exploring the use of a hormone called human chorionic gonadotropin, which occurs naturally in the body. | |
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| Drs. Trifiro, Pinsky, Miller, Alpert and Ghadirian | Length of the CAG Repeat in the Androgen Receptor Gene in Breast Cancer |
| Drs. Trifiro and Pinsky have found variations between people in the length of specific encoding on the gene encoding the androgen receptor. They are exploring preliminary findings that in breast cancer the receptor is shorter. It is possible that this work will identify a new test for breast cancer risk, as well as potential new avenues for treatment. | |
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| Drs. Laird, Jamali and Alpert | Mechanism of gap junction down regulation in mammary tumor cells and potential therapeutic implication in breast cancer |
| Cells normally communicate through channels called "gap junctions". A critical feature in the development of cancer is the loss of this communication. This team has now demonstrated this to be the case in human breast cancer. Precisely how and why this occurs, and how it could be restored is the aim of this work. | |
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| Drs. Brodt and Alpert | The role of the regional lymph node stroma in breast carcinoma progression |
| This team is exploring the interaction between breast cancer cells and the normal cells with which they make contact. This interaction could stimulate or inhibit tumor cell growth, and the project aims to understand whether this can be manipulated to therapeutic advantage. | |